microtubule inhibitor 3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62867	Microtubule inhibitor 3
	Compounds 17o (IC50: 14.0 nM, NCI-H460) and 17p (IC50: 2.9 nM, NCI-H460) with furan moieties showed potent cytotoxic effects at the nanomolar level against various human cancer cell lines.
T60026	KIF18A-IN-2		Microtubule Associated
	KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.		Microtubule Associated
T1910	Ansamitocin P 3'	Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3'	Microtubule Associated
	Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.		Microtubule Associated
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.		Microtubule Associated
T6212	Combretastatin A4	CA4,CRC 87-09	Microtubule Associated
	Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).		Microtubule Associated
T1152	Albendazole	SKF-62979	HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
	Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T15576	Indibulin	ZIO 301,D 24851	Apoptosis , Microtubule Associated
	Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...		Apoptosis , Microtubule Associated
T0320	Colchicine	Colcin,Colchineos,Colchisol	Apoptosis , Microtubule Associated , Autophagy
	Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of...		Apoptosis , Microtubule Associated , Autophagy
T22262	Ansamitocin p-3	Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222	Microtubule Associated
	Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.		Microtubule Associated
T24646	PK-3	CID-20959075,CID 20959075,CID20959075
	PK-3 is a cancer cell growth inhibitor. It also has microtubule-binding activity.
T62448	Microtubule inhibitor 6
	Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r...
T62642	Microtubule inhibitor 4
	Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity.
T10928	Cytochalasin A		HIV Protease
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu...		HIV Protease
T37063	Laulimalide
	Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, pre...
T70527	DAT-230
	DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -tr...
T71217	MPT0B214
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activ...
T70006	DHA-paclitaxel
	DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells t...
T83874	S-72
	S-72 acts as a microtubule polymerization inhibitor, effective in cell-free assays at concentrations of 1, 3, and 10 µM. At nanomolar levels (IC50s = 15.64 and 26.32 nM, respectively), it diminishes the viability of both...